A New Perspective On Carcinogenesis

Organic acids and mitochondria

The proposed theory allows us to make as a puzzle of a single picture of many facts, including the fact of the positive impact of succinic acid in energy exchange. In previous theories, all these details had to be avoided, as they are poorly combined with each other.

Succinic acid is involved in energy metabolism in all human tissues, promotes the activation of this exchange — gives us energy, helps to adapt to the negative effects of the environment, when the cells are suffocated by lack of oxygen (hypoxia), increases the body’s resistance to oxygen starvation. The action of succinic acid is most pronounced in adverse, extreme conditions. The drug helps to reduce the blood ketone bodies, glucose, reduces hydroperoxide self-oxidation and intoxication in cells, improves the work of affected mitochondria.

In the usual sequence of reactions in the mitochondria — in the Krebs cycle — succinic acid is one of the intermediate compounds. As shown by the research of the Institute of theoretical and experimental Biophysics of RAS, the energy power of ATP synthesis in the oxidation of succinic acid is significantly higher than in the oxidation of any other substrate.

Cancer cells have an abnormality in mitochondrial function, which makes them a type of anaerobic glycolysis. All this determines the feasibility of using this type of oxygenators in order to transfer anaerobic cancer cells to higher levels of aerobicity. The imposition of the onkokletok the transition from anaerobic to aerobic fitness attenuates the aggressiveness (excessive rapid growth) and malignancy. The tumor is becoming less dangerous.

In addition, succinic acid (amber) not only enhances the catabolism of cells, but also due to its specific properties helps to restore the disturbed energy processes when they begin to connect the mitochondria. Obviously, this specific side of succinic acid is much more important than the catabolic properties of other organic acids.

For my part, I note that this is well coordinated with the concept of the primacy of the membrane stage of the formation of the pre-cancer. I think a more correct interpretation is the decrease in the sensitivity of genes to substrates and the need for several generations of regeneration, so that mitochondria can repair.

Also, mitochondria in the cell have another very important function — they include the mechanism of apoptosis, genetically programmed cell death. When ” off “(reduced sensitivity) mitochondria off and apoptosis, cancer cells become” immortal ” and displace over time normal cells from the tumor. Mitochondria, “resuscitated” by DCA, again cause apoptosis, and the process of development and death of cells returns to normal. Preparirovanie cells displace over time onkokletki of the tumor.

Features of the complex of natural fruit acids

The advantage of using a complex of natural fruit acids is that it has the most complete set of natural acids, including the Krebs cycle in mitochondria, which inhibit the glycolysis of diseased cells and stimulate the mitochondria of cancer cells. Where there are metabolites of aerobic processes, anaerobic glycolysis subside. Organic metabolites also have the signal function necessary for the inclusion of genes.

The high concentration of fruit acids creates a tense substrate field in the cytoplasm of cells. This “tense situation “is similar to the one when you need a more powerful starter to start the ” broken” generator. The sensitivity threshold of the gene cascade, reacting to this substrate, becomes available for homeostatic response of mitochondrial genes, which is able to connect genes that are not working in them normally. Moreover, not a part of the genes responsible for each substrate reacts and connects, but the whole complex, a sequential cascade of different genes consisting of batteries of the same genes involved in energy processes. Newly earned mitochondria are capable of self-healing and repair. Apparently, that’s what they needed that kind of help for.

There is evidence that mitochondria can restore their DNA, but this is only possible when the mechanism of fusion of two mitochondria is started. In patients with cells, this mechanism of fusion and repair does not work. Normally, this block of genes, each of which consists of a repeatedly repeated battery of the same genes, is programmed to work until the state of the substrate field changes and the ratio of acids and carbohydrates goes in one case in favor of carbohydrates, and in the other — acids. The achieved gradient of carbohydrates, respectively, can slow down the work of controlling genes. As a result, the work of mitochondria will be dramatically restructured.

At the same time, the composition of fruit acids introduced into treatment has mainly a different composition of acids (intended for construction, synthesis) in contrast to those obtained as a result of respiration and metabolic disintegration. This is not garbage (like lactic, uric and similar acids, which are metabolites of defective glycolysis metabolism), not the products of decay (catabolism). Therefore, not all acids are suitable. Only anabolic acids for synthesis can, saturating cells, fully launch a cascade of non-working genes.

In the pathogenesis of cancer of animal cells inhibition of mitochondria occurs not as a consequence of certain programs, but as aberrations [7] at the level of membranes and mitochondria. Energy capacity of mitochondria weakens due to violations of the structure of the membranes of both cellular and mitochondrial. They determine the quality and usefulness of the whole enzyme system through the genome. Membrane permeability there is a similar “broken pot” in which the blood pressure, and automatic valves (mitochondria) hardly support the normal pressure, is gradually electronic relay (mitochondrial DNA) is also out of order.

Also suffers bilateral polarization of membranes, their buffer resistance and the usefulness of enzymes associated with it because of the insufficiently stressed internal environment of cells, determined by the cell membrane. In addition, due to the poor mitochondrial membranes their efficiency, performance is also reduced, they begin to work half-heartedly. Such mitochondria are forced, as compensation, to dramatically intensify their activities in the same way as a peddling engine. In a combination of lack of antioxidants, buffer systems, protective substances in them may prevail “peroxide fire”, “energy overheating”, leading to DNA damage mitochondria. The cells seem to enter the stasis, a dead end, do not react to the previous substrate field. Their functional significance is reduced, they are less sensitive to stimulating factors or more vulnerable to external influences. It is the increase in the gradient of the substrate field, which exceeds the level of the previous homeostatic constants, that leads to the launch of the remaining unused truncated cascade of mitochondrial genes. They reconnect to the process.

The whole process described is characteristic of many aging tissues. But it is still not cancer, as a starting point, the background required to neogenesis. The very same neogenesis is a qualitative leap in the transition of the process to a new and already irreversible and unregulated state. This means that a new understanding of Neogene — not a single transition, not some mutation of cells, how it was treated before, and the whole step process predisposing transitions, accumulation conditions, bases of rebirth in the organelles of cells. Mitochondria in cells can be hundreds, and all of them can not be reborn. In the future, it is enough to throw in the soil prepared for change and even provoking factor to cause cell degeneration. For the manifestation of neogenesis, a combination of predisposing and provoking factors is necessary. Therefore, I proposed to introduce the term cell aberration instead of the former — mutation. And do these cells should be called aberrant.

To return such a new stable system to its original state of metabolism, stronger levers of influence on their metabolism are needed. You need to conduct a system through a series of sequential intracellular samarappuli.

At the same time, to secure a stable result, it is necessary to simultaneously restore the outer membranes of cells and mitochondria. This need for licensemenu fatty acids such as omega-3. This will also contribute to the restoration of the intracellular antioxidant defense system (selenium, Q10).

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